New cephalosporin antibiotics with 3-triazolylpyridiniummethyl substituents.
نویسندگان
چکیده
(pyrazol-3-yl)pyridmium group at the C-3' position as a combination of the pyridine moiety of ceftazidime2) and the pyrazole moiety of cefoselis3) to attain a synergic effect in activity. As we expected, those compoundsexhibited wellbalanced and broad spectrum of activity against Grampositive and Gram-negative bacteria. Of them, 7-[(Z)-2-(2aminol ,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3[(3 -(5-amino-pyrazol-3 -yl)pyridinium)methyl] -3 -cephem4-carboxylic acid (la)1) showed the best activity
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 54 5 شماره
صفحات -
تاریخ انتشار 2001